Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.51 |
| ▸ | HTR1B | P28222 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1775137 | 0.99 | HTR6 (0.50) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL1775401 | 0.89 | HRH4 (0.45) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1774702 | 0.88 | HRH4 (0.44) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL1775535 | 0.85 | FLT3 (0.46) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1773881 | 0.84 | FLT3 (0.45) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL1775441 | 0.84 | HTR6 (0.45) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL1775491 | 0.83 | HTR6 (0.45) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL5015937 | 0.79 | HRH4 (0.46) | HTR1AHTR2AHTR1DHTR1BDRD2 | |
| SCHEMBL1777009 | 0.78 | MALT1 (0.48) | HTR6HTR1AHTR2AHTR1DHTR1B | |
| SCHEMBL1774831 | 0.77 | HTR6 (0.50) | HTR6HTR1AHTR2AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |