SCHEMBL1774615

SCHEMBL1774615

Cc1ccc(CBr)cc1Br

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 5/20 0.39
ALDH1A1 P00352 4/20 0.39
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
NPC1 O15118 2/20 0.36
NR2F2 P24468 1/20 0.36
NOD2 Q9HC29 1/20 0.36
TSHR P16473 2/20 0.35
TRPA1 O75762 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CES2 O00748 1/20 0.33
CES1 P23141 1/20 0.33
KDM4E B2RXH2 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29783216 1.00 HPGD (0.39) HPGDALDH1A1CYP4F2CYP4A11NPC1
SCHEMBL17704659 0.83 ESR1 (0.48) HPGDALDH1A1NPC1NR2F2NOD2
SCHEMBL10257025 0.81 HPGD (0.43) HPGDALDH1A1NPC1TRPA1CYP1A2
SCHEMBL308275 0.81 ALDH1A1 (0.39) ALDH1A1CYP4F2CYP4A11NPC1TSHR
SCHEMBL29427134 0.81 ALDH1A1 (0.39) ALDH1A1CYP4F2CYP4A11NPC1TSHR
SCHEMBL539541 0.80 ALDH1A1 (0.40) ALDH1A1CYP4F2CYP4A11NPC1TSHR
SCHEMBL29559999 0.80 ALDH1A1 (0.40) ALDH1A1CYP4F2CYP4A11NPC1TSHR
SCHEMBL3398586 0.79 HRH3 (0.39) HPGDALDH1A1GAAMAPT
SCHEMBL11495289 0.79 HPGD (0.38) HPGDALDH1A1NPC1NR2F2NOD2
SCHEMBL1363463 0.79 HRH3 (0.39) HPGDALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727654-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF Mariana Oncology Inc. (US) 2026-04-22 EP disclosed
EP-4727655-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF Mariana Oncology Inc. (US) 2026-04-22 EP disclosed
EP-4727653-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF Mariana Oncology Inc. (US) 2026-04-22 EP disclosed
US-20250296959-A1 B7-H3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF MARIANA ONCOLOGY INC (US) 2025-09-25 US disclosed
US-20250205373-A1 ENRICHED AND STABLE RADIOLIGAND THERAPY FORMULATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME MARIANA ONCOLOGY INC (US) 2025-06-26 US disclosed
WO-2025122615-A1 ENRICHED AND STABLE RADIOLIGAND THERAPY FORMULATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME MARIANA ONCOLOGY INC. (US) 2025-06-12 WO disclosed
US-20250186541-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF MARIANA ONCOLOGY INC (US) 2025-06-12 US disclosed
EP-4565258-A2 COMPOSITIONS FOR THE TREATMENT OF DISEASE Sightstream Biotherapeutics, Inc. (US) 2025-06-11 EP disclosed
US-20250179691-A1 MULTIVALENT GLYCOPEPTIDES THAT TIGHTLY BIND TO CARBOHYDRATE-BINDING MONOCLONAL ANTIBODY FAMILY PGT128 BRANDEIS UNIVERSITY (US) 2025-06-05 US disclosed
US-12247320-B2 Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family PGT128 BRANDEIS UNIVERSITY (US) 2025-03-11 US disclosed
EP-1294789-A1 REVERSIBLE CROSSLINKED POLYMERS, BENZYL CROSSLINKERS AND METHOD BATTELLE MEMORIAL INSTITUTE (US) 2003-03-26 EP disclosed
US-6479498-B1 COMPRISE 2-10 SODIUM CHANNEL LIGANDS COVALENTLY CONNECTED BY A LINKER OR LINKERS THERAVANCE, INC. 2002-11-12 US disclosed
US-6420354-B1 Sodium channel drugs and uses ADVANCED MEDICINE, INC. 2002-07-16 US disclosed
WO-2001092366-A1 REVERSIBLE CROSSLINKED POLYMERS, BENZYL CROSSLINKERS AND METHOD BATTELLE MEMORIAL INSTITUTE (US) 2001-12-06 WO disclosed
WO-2001090101-A1 ARYLMETHYLAMINE DERIVATIVES FOR USE AS TRYPTASE INHIBITORS AVENTIS PHARMACEUTICALS INC. (US) 2001-11-29 WO disclosed
EP-1112998-A1 AMINE DERIVATIVES POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-07-04 EP disclosed
EP-0318935-B1 Substituted alpha-amino acids having pharmaceutical activity WARNER LAMBERT CO (US) 1995-02-01 EP disclosed
US-5175153-A Antiischemic agents or antiepileptic agents WARNER-LAMBERT COMPANY (US) 1992-12-29 US disclosed
EP-0421436-A2 Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity WARNER-LAMBERT COMPANY (US) 1991-04-10 EP disclosed
EP-0318935-A2 Substituted alpha-amino acids having pharmaceutical activity WARNER-LAMBERT COMPANY (US) 1989-06-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179691-A1 MULTIVALENT GLYCOPEPTIDES THAT TIGHTLY BIND TO CARBOHYDRATE-BINDING MONOCLONAL ANTIBODY FAMILY PGT128 CSGALNACT1, STT3A, STT3B HPGD 4402/4885ALDH1A1 4633/4885CYP4F2 3507/4885
US-20250186541-A1 DLL3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF DLK1, DBNL, PDLIM5 HPGD 4598/4885ALDH1A1 4342/4885CYP4F2 4796/4885
US-20250296959-A1 B7-H3 TARGETING PEPTIDES AND CONSTRUCTS THEREOF CD274, CD44, CD74 HPGD 2692/4885ALDH1A1 3394/4885CYP4F2 4780/4885
US-20250205373-A1 ENRICHED AND STABLE RADIOLIGAND THERAPY FORMULATIONS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME ASGR1, GPR119, LDLR HPGD 1338/4885ALDH1A1 2722/4885CYP4F2 2200/4885
US-12247320-B2 Multivalent glycopeptides that tightly bind to carbohydrate-binding monoclonal antibody family PGT128 CSGALNACT1, STT3A, GALNT14 HPGD 4216/4885ALDH1A1 4399/4885CYP4F2 4056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.