Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774685 | 1.00 | HRH3 (0.55) | HRH3HRH4PDPK1ROCK1AURKB | |
| SCHEMBL3083698 | 0.85 | PDPK1 (0.58) | PDPK1ROCK1AURKBAURKA | |
| SCHEMBL1774333 | 0.84 | HRH3 (0.63) | HRH3HRH4 | |
| SCHEMBL2448685 | 0.78 | CRHBP (0.61) | HRH3HRH4PDPK1ROCK1AURKB | |
| SCHEMBL1318430 | 0.77 | CYP1A2 (0.60) | PDPK1ROCK1AURKBAURKA | |
| SCHEMBL604610 | 0.77 | HRH4 (0.71) | HRH3HRH4 | |
| SCHEMBL1773938 | 0.76 | HRH4 (0.79) | HRH3HRH4 | |
| SCHEMBL1774835 | 0.76 | HRH4 (0.78) | HRH3HRH4 | |
| SCHEMBL604367 | 0.76 | HRH4 (0.73) | HRH3HRH4 | |
| SCHEMBL602443 | 0.72 | HRH4 (0.64) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| EP-1966162-A2 | PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| US-20070185075-A1 | Pyrimidine derivatives | PFIZER LIMITED | 2007-08-09 | — | — | US | disclosed |
| WO-2007072163-A2 | PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185075-A1 | Pyrimidine derivatives | TYMS, DPYD, TYMP | HRH3 187/4885HRH4 184/4885PDPK1 1496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.