Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TAF1 | P21675 | 1/20 | 0.51 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.51 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 8/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17754063 | 0.82 | BRD4 (0.71) | ALDH1A1TP53LMNATAF1CECR2 | |
| SCHEMBL17753671 | 0.77 | BRD4 (0.52) | ALDH1A1LMNATAF1CECR2BRD9 | |
| SCHEMBL17754065 | 0.76 | PDE10A (0.53) | TP53LMNATAF1CECR2BRD9 | |
| SCHEMBL17754064 | 0.76 | BRD9 (0.55) | ALDH1A1RAB9ATAF1CECR2BRD9 | |
| SCHEMBL17753983 | 0.75 | BRD9 (0.66) | ALDH1A1MAPK1TAF1CECR2BRD9 | |
| SCHEMBL17754174 | 0.74 | CECR2 (0.59) | TAF1CECR2BRD9BRD4 | |
| SCHEMBL17749030 | 0.73 | TAF1 (0.61) | TAF1CECR2BRD9KMT2ABRD4 | |
| SCHEMBL17753895 | 0.73 | TAF1 (0.58) | ALDH1A1LMNATAF1CECR2BRD9 | |
| SCHEMBL17753695 | 0.73 | TAF1 (0.58) | RAB9ATAF1CECR2BRD9NPC1 | |
| SCHEMBL17753997 | 0.73 | TAF1 (0.64) | ALDH1A1MAPK1LMNATAF1CECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | ALDH1A1 1563/4885RAB9A 1828/4885TP53 1133/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | ALDH1A1 1563/4885RAB9A 1828/4885TP53 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.