Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.51 |
| ▸ | TAF1 | P21675 | 1/20 | 0.51 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17754058 | 0.87 | BRD4 (0.55) | PDE10ABRD4MAPTLMNABRD9 | |
| SCHEMBL17754063 | 0.86 | BRD4 (0.71) | PDE10ABRD4TP53MAPTLMNA | |
| SCHEMBL17753776 | 0.84 | BRD4 (0.54) | BRD4BRD9TAF1CECR2 | |
| SCHEMBL17753671 | 0.77 | BRD4 (0.52) | BRD4LMNABRD9TAF1CECR2 | |
| SCHEMBL17754069 | 0.76 | ALDH1A1 (0.51) | BRD4TP53MAPTLMNABRD9 | |
| SCHEMBL17754064 | 0.76 | BRD9 (0.55) | BRD4BRD9TAF1CECR2ADORA2A | |
| SCHEMBL17748992 | 0.75 | CECR2 (0.57) | BRD4BRD9TAF1CECR2 | |
| SCHEMBL17754174 | 0.74 | CECR2 (0.59) | BRD4BRD9TAF1CECR2 | |
| SCHEMBL12821472 | 0.74 | HDAC1 (0.61) | TP53LMNAHDAC1ADORA2AADORA1 | |
| SCHEMBL17749030 | 0.73 | TAF1 (0.61) | PDE10ABRD4BRD9TAF1CECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | PDE10A 1615/4885BRD4 1/4885TP53 1133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.