Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.44 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775766 | 0.91 | HTR2C (0.40) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1777100 | 0.89 | HTR6 (0.46) | HTR6HTR2CDRD2USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5012454 | 0.88 | HTR2C (0.39) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1775164 | 0.86 | HTR2C (0.37) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1776423 | 0.81 | HTR6 (0.45) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1775605 | 0.81 | HTR6 (0.56) | HTR6HTR2CHTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1775612 | 0.80 | HTR6 (0.55) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL6386482 | 0.79 | HTR6 (0.45) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL5015941 | 0.78 | HTR2C (0.53) | HTR6HTR2CHTR1ADRD2HTR7 | |
| SCHEMBL1775896 | 0.77 | HTR6 (0.53) | HTR6HTR2CHTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| EP-1897881-A2 | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | disclosed |