Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775564 | 0.91 | HTR6 (0.44) | HTR2CHTR6USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL5012454 | 0.89 | HTR2C (0.39) | HTR2CHTR6USP2TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL1775164 | 0.86 | HTR2C (0.37) | HTR2CHTR6USP2TSHRHSD17B10 | |
| SCHEMBL1777100 | 0.84 | HTR6 (0.46) | HTR2CHTR6NCF1USP2TSHR | |
| SCHEMBL6385040 | 0.81 | HTR6 (0.47) | HTR2CHTR6HTTNCF1HTR1A | |
| SCHEMBL1774379 | 0.80 | HTR2C (0.39) | HTR2CHTR6HTTNCF1USP2 | |
| SCHEMBL1775615 | 0.78 | HTR6 (0.45) | HTR2CHTR6HTTNCF1 | |
| SCHEMBL6543494 | 0.78 | HTR2C (0.42) | HTR2CHTR6HTTNCF1HTR1A | |
| Hydrochloric Acid SCHEMBL1775901 | 0.77 | HTR6 (0.44) | HTR2CHTR6HTTNCF1 | |
| SCHEMBL1777105 | 0.77 | HTR2C (0.45) | HTR2CHTR6HTTNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |
| EP-1897881-A2 | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | disclosed |