Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757363 | 0.91 | LMNA (0.32) | LMNA | |
| SCHEMBL17757846 | 0.91 | LMNA (0.39) | HTTLMNA | |
| SCHEMBL17757080 | 0.90 | ACAT2 (0.38) | HTTLMNA | |
| SCHEMBL17758067 | 0.89 | LMNA (0.32) | LMNA | |
| SCHEMBL17758070 | 0.89 | KDM4E (0.36) | LMNA | |
| SCHEMBL17757372 | 0.89 | KDM4E (0.34) | LMNA | |
| SCHEMBL17758054 | 0.89 | KCNH3 (0.34) | LMNA | |
| SCHEMBL17757109 | 0.88 | ACAT2 (0.36) | ELANEHTTESR1 | |
| SCHEMBL17992081 | 0.88 | NPC1 (0.36) | LMNA | |
| SCHEMBL17757092 | 0.88 | ELANE (0.36) | ELANELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075137-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2016-05-19 | — | — | WO | disclosed |