Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774900 | 0.99 | HTR6 (0.60) | HTR6HTR1ADRD2HTR7CYP1A2 | |
| SCHEMBL1775359 | 0.80 | HTR6 (0.64) | HTR6HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1776556 | 0.79 | HTR6 (0.63) | HTR6HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL6463228 | 0.79 | HTR6 (0.60) | HTR6HTR1ADRD2HTR7 | |
| SCHEMBL1776123 | 0.79 | HTR6 (0.79) | HTR6HTR1ADRD2HTR7 | |
| SCHEMBL1776061 | 0.79 | HTR6 (0.62) | HTR6HTR1ADRD2HTR7HTR2C | |
| Hydrochloric Acid SCHEMBL1776042 | 0.78 | HTR6 (0.78) | HTR6HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL1774491 | 0.78 | HTR6 (0.61) | HTR6HTR1ADRD2HTR7HTR2C | |
| SCHEMBL1775946 | 0.77 | HTR6 (0.69) | HTR6HTR2C | |
| SCHEMBL1776812 | 0.76 | HTR6 (1.00) | HTR6HTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |