Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776644 | 0.99 | LMNA (0.39) | LMNAPKMSMN1; SMN2HRH4ADORA3 | |
| SCHEMBL1775987 | 0.91 | HTT (0.39) | LMNAPKMSMN1; SMN2HTR6HTR1A | |
| Hydrochloric Acid SCHEMBL1774418 | 0.90 | HTT (0.39) | LMNAPKMSMN1; SMN2HTR6HTR1A | |
| SCHEMBL1775387 | 0.82 | HRH4 (0.39) | HRH4HTR2ADRD3 | |
| SCHEMBL1775433 | 0.81 | HTR6 (0.40) | HTR6HTR1AHTR2AHTR7HTR1D | |
| SCHEMBL1774845 | 0.78 | HRH4 (0.37) | HRH4HTR6HTR1AHTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL1775293 | 0.78 | HRH4 (0.36) | HRH4HTR6HTR1AHTR2AHTR7 | |
| SCHEMBL1775401 | 0.77 | HRH4 (0.45) | LMNAPKMSMN1; SMN2HRH4ADORA3 | |
| SCHEMBL1776120 | 0.77 | KIT (0.39) | HTR6HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL1775562 | 0.76 | KIT (0.38) | HTR6HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |