Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Dyclonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | HRH2 | P25021 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | ACHE | P22303 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29766083 | 1.00 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL317219 | 0.99 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL1649948 | 0.97 | THRB (0.95) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL11231907 | 0.96 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9320014 | 0.96 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9320006 | 0.96 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL9319585 | 0.96 | THRB (1.00) | THRBALDH1A1LMNAHRH2HRH1 | |
| Dyclonine SCHEMBL8662373 | 0.95 | THRB (0.90) | THRBALDH1A1LMNAHRH2HRH1 | |
| Hydrochloric Acid SCHEMBL11234596 | 0.95 | THRB (0.98) | THRBALDH1A1LMNAHRH2HRH1 | |
| SCHEMBL29378842 | 0.95 | ALDH1A1 (0.97) | THRBALDH1A1LMNAHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8738 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026106952-A1 | METHODS FOR TREATING CONGENITAL DISORDERS OF GLYCOSYLATION | CDG CARE (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4231960-B1 | DENTAL KIT COMPRISING A DENTAL ALIGNER OR A MOUTH TRAY AND DISSOLVABLE FILMS | BSOLVE LTD (GB) | 2026-04-15 | — | — | EP | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| EP-4694866-A1 | SUSTAINED RELEASE STABLE EMULSION PHARMACEUTICAL FORMULATIONS | Insitu Biologics, Inc. (US) | 2026-02-18 | — | — | EP | claimed |
| EP-4680203-A1 | COMPOSITIONS FOR SUSTAINED RELEASE OF POORLY SOLUBLE ACTIVE INGREDIENTS | Prolevi Bio AB (SE) | 2026-01-21 | — | — | EP | claimed |
| US-20260007753-A1 | DERMAL SKIN PROTECTANT AND CARRIER | INSPIRED MAT STRATEGIES LLC (US) | 2026-01-08 | — | — | US | claimed |
| WO-2025235864-A1 | COATED NEEDLE ADMINISTRATION SYSTEMS | EVOLUS, INC. (US) | 2025-11-13 | — | — | WO | claimed |
| US-20250319047-A1 | ANTIMICROBIAL TREATMENT AND PREVENTION BY PERILLYL ALCOHOL AND DERIVATIVES | ZAYAS RIVERA JOSE (US) | 2025-10-16 | — | — | US | claimed |
| EP-4629992-A1 | DYCLONINE FOR USE IN THE TOPICAL TREATMENT OF HAND-FOOT SYNDROME | ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS (FR) | 2025-10-15 | — | — | EP | claimed |
| US-12419959-B2 | Dermal skin protectant and carrier | Inspired Material Strategies, LLC (US) | 2025-09-23 | — | — | US | claimed |
| EP-0431376-A1 | Hard confections containing hydrogenated isomaltulose and a medicinally active ingredient | SÜDZUCKER AKTIENGESELLSCHAFT MANNHEIM/OCHSENFURT (DE) | 1991-06-12 | — | — | EP | claimed |
| US-5002974-A | Oil phase with nonionic surfactant, water phase with thickener for emulsions for skin | WARNER-LAMBERT CO. (US) | 1991-03-26 | — | — | US | claimed |
| US-4971798-A | ANTITUSSIVE, DECONGESTANT, ANTIHISTAMINE OR EXPECTORANT | MILES INC. (US) | 1990-11-20 | — | — | US | claimed |
| CN-1046281-A | Aerosols for protective film of medicine \" Hemostatic-Yantongting \ | SHI GUANGSHENG (CN) | 1990-10-24 | — | — | CN | claimed |
| EP-0383481-A2 | Anesthetic oral compositions | Richardson-Vicks, Inc. (US) | 1990-08-22 | — | — | EP | claimed |
| US-4931473-A | BETA-AMINO PROPIOPHENONES WITH SACCHARIN STABILIZER; THROAT LOZENGES | RICHARDSON-VICKS INC. (US) | 1990-06-05 | — | — | US | claimed |
| US-4917894-A | DICYCLONINE, HEXYLRESORCINOL OR BENZOCAINE; THROAT SPRAY, LOZENGE | BEECHAM INC. (US) | 1990-04-17 | — | — | US | claimed |
| EP-0336901-A2 | Anesthetic skin moisturizing composition and method of preparing same | WARNER-LAMBERT COMPANY (US) | 1989-10-11 | — | — | EP | claimed |
| EP-0152379-A2 | Process for preparing pharmaceutical compositions containing unilamellar liposomes | CIBA-GEIGY AG (CH) | 1985-08-21 | — | — | EP | claimed |
| US-4333941-A | Inhibition of enveloped viruses with phenyl ketones | THE DOW CHEMICAL COMPANY (US) | 1982-06-08 | — | — | US | claimed |