Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | SLC8A1 | P32418 | 7/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360502 | 0.83 | ESR1 (0.63) | ABCB1ARABCG2FFAR1LMNA | |
| SCHEMBL2960656 | 0.80 | LMNA (0.55) | ABCB1ARABCG2FFAR1LMNA | |
| SCHEMBL29974296 | 0.80 | LMNA (0.55) | ABCB1ARABCG2FFAR1LMNA | |
| SCHEMBL11053487 | 0.79 | ABCB1 (0.61) | ABCB1ARABCG2CYP19A1SLC8A1 | |
| SCHEMBL22882748 | 0.78 | FFAR1 (0.49) | ABCB1ARABCG2FFAR1LMNA | |
| SCHEMBL19230618 | 0.77 | ESR2 (0.72) | ARFFAR1TDP1CYP19A1SLC8A1 | |
| SCHEMBL19230614 | 0.77 | ESR1 (0.50) | CYP19A1SLC8A1MAOBGABRA1GABRB2 | |
| SCHEMBL16160573 | 0.76 | ESR2 (0.63) | FFAR1LMNACYP19A1ESR1ESR2 | |
| SCHEMBL17708841 | 0.74 | ABCB1 (0.62) | ABCB1ARABCG2LMNACYP19A1 | |
| SCHEMBL17708839 | 0.74 | ABCB1 (0.62) | ABCB1ARABCG2LMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212189-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | AbbVie S.À.R.L. (LU) | 2017-09-06 | — | — | EP | claimed |
| WO-2016069757-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | ABBVIE INC. (US) | 2016-05-06 | — | — | WO | claimed |
| EP-3212189-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | AbbVie S.À.R.L. (LU) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069757-A1 | SUBSTITUTED CHROMANES AND METHOD OF USE | ABBVIE INC. (US) | 2016-05-06 | — | — | WO | disclosed |