Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.49 |
| ▸ | CDK8 | P49336 | 5/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | ROS1 | P08922 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297592 | 0.83 | RIPK1 (0.47) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL29543783 | 0.83 | RIPK1 (0.47) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL17616439 | 0.82 | RIPK1 (0.46) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL1328372 | 0.82 | RIPK1 (0.49) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL1329244 | 0.81 | CDK8 (0.58) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL2013329 | 0.79 | RIPK1 (0.51) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL298150 | 0.79 | RIPK1 (0.69) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL293195 | 0.79 | RIPK1 (0.51) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL4831625 | 0.79 | CYP2A6 (0.43) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL297547 | 0.79 | KDR (0.47) | RIPK1CDK8AXLPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873680-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| WO-2016033243-A9 | ANTIRETROVIRAL AGENTS | GILEAD SCIENCES, INC. (US) | 2016-05-19 | — | — | WO | disclosed |