Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.51 |
| ▸ | CDK8 | P49336 | 9/20 | 0.50 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | FER | P16591 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293195 | 0.81 | RIPK1 (0.51) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL298150 | 0.81 | RIPK1 (0.69) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL17761629 | 0.79 | RIPK1 (0.49) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL1329244 | 0.77 | CDK8 (0.58) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL297592 | 0.76 | RIPK1 (0.47) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL29543783 | 0.76 | RIPK1 (0.47) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL17616439 | 0.75 | RIPK1 (0.46) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL1328372 | 0.75 | RIPK1 (0.49) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL4831501 | 0.74 | CDK8 (0.81) | RIPK1CDK8AXLPIK3CDPIK3CA | |
| SCHEMBL5262714 | 0.74 | RIPK1 (0.44) | RIPK1CDK8AXLPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703961-B2 | Thiazole derivatives for the treatment of diseases such as cancer | MERCK PATENT GMBH (DE) | 2014-04-22 | — | — | US | disclosed |
| EP-2513071-A1 | THIAZOLE DERIVATIVES FOR TREATING DISEASES SUCH AS CANCER | Merck Patent GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-20120252759-A1 | THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GESELLSCHAFT MIT BESCHRANKER HAFTING (DE) | 2012-10-04 | — | — | US | disclosed |
| WO-2011072779-A1 | THIAZOLE DERIVATIVES FOR TREATING DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252759-A1 | THIAZOLE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | RET, IGF1R, JAK2 | RIPK1 1021/4885CDK8 327/4885AXL 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.