Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | CDK8 | P49336 | 8/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | ROS1 | P08922 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297592 | 1.00 | RIPK1 (0.47) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL17761629 | 0.83 | RIPK1 (0.49) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL17616439 | 0.79 | RIPK1 (0.46) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL1329244 | 0.79 | CDK8 (0.58) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL18762343 | 0.77 | PDE3B (0.37) | PIK3CGMAPK1 | |
| SCHEMBL503744 | 0.77 | BRAF (0.39) | PIK3CAFGFR1ABL1PDGFRALRRK2 | |
| SCHEMBL1328372 | 0.76 | RIPK1 (0.49) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL293195 | 0.76 | RIPK1 (0.51) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL2013329 | 0.76 | RIPK1 (0.51) | RIPK1CDK8AXLPIK3CAPIK3CD | |
| SCHEMBL298150 | 0.76 | RIPK1 (0.69) | RIPK1CDK8AXLPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022074379-A1 | METTL3 INHIBITORY COMPOUNDS | STORM THERAPEUTICS LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |