Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.81 |
| ▸ | GABRA5 | P31644 | 15/20 | 0.72 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778133 | 0.95 | GABRA1 (0.73) | GABRA1GABRA5 | |
| SCHEMBL29421328 | 0.90 | GABRA1 (1.00) | GABRA1 | |
| SCHEMBL20240975 | 0.90 | GABRA1 (1.00) | GABRA1 | |
| SCHEMBL1776648 | 0.86 | ITGA5 (0.83) | GABRA1GABRA5ITGA5 | |
| SCHEMBL2930330 | 0.83 | GABRA5 (1.00) | GABRA5ITGA5 | |
| SCHEMBL1776889 | 0.83 | GABRA5 (0.58) | GABRA1GABRA5 | |
| SCHEMBL286119 | 0.83 | GABRA5 (0.72) | GABRA5ITGA5 | |
| SCHEMBL1776887 | 0.83 | GABRA5 (0.67) | GABRA1GABRA5 | |
| SCHEMBL2928005 | 0.82 | GABRA5 (1.00) | GABRA1GABRA5ITGA5 | |
| SCHEMBL1778114 | 0.82 | GABRA5 (0.59) | GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |