Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 5/20 | 0.44 |
| ▸ | SNCA | P37840 | 5/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17762732 | 1.00 | MAPT (0.55) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL17762754 | 0.83 | MAPT (0.63) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL4135006 | 0.77 | CYP19A1 (0.57) | MAOBMAOA | |
| SCHEMBL2622601 | 0.76 | MAOB (0.70) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL137664 | 0.76 | MAOB (0.70) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL2622613 | 0.76 | MAOB (0.70) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL11451994 | 0.75 | HDAC3 (0.59) | APPNFE2L2AHRMAOBMAOA | |
| SCHEMBL2622607 | 0.75 | HDAC3 (0.59) | APPNFE2L2AHRMAOBMAOA | |
| SCHEMBL8064186 | 0.74 | CMA1 (0.61) | MAPTNPC1POLBMAPK1RECQL | |
| SCHEMBL18416524 | 0.74 | MAOB (0.67) | MAPTNPC1POLBMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077793-A1 | SOS1 INHIBITORS FOR CANCER TREATMENT | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2016-05-19 | — | — | WO | disclosed |