Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.63 |
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | CMA1 | P23946 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 3/20 | 0.58 |
| ▸ | SNCA | P37840 | 3/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064186 | 0.90 | CMA1 (0.61) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL13104436 | 0.83 | CMA1 (0.63) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL28404789 | 0.83 | CMA1 (0.63) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL17762732 | 0.83 | MAPT (0.55) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL17762702 | 0.83 | MAPT (0.55) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL16160384 | 0.80 | MAPT (0.74) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL1239938 | 0.78 | MAPT (0.50) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL1239940 | 0.78 | MAPT (0.50) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL23458007 | 0.76 | MAOB (1.00) | MAPTMAPK1POLBRAB9ANPC1 | |
| SCHEMBL5875512 | 0.76 | MAOB (1.00) | MAPTMAPK1POLBRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077793-A1 | SOS1 INHIBITORS FOR CANCER TREATMENT | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2016-05-19 | — | — | WO | disclosed |