Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.74 |
| ▸ | APP | P05067 | 8/20 | 0.74 |
| ▸ | SNCA | P37840 | 8/20 | 0.74 |
| ▸ | METAP1 | P53582 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MITF | O75030 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762229 | 0.85 | MAPT (1.00) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL16160398 | 0.84 | MAPT (0.79) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL11598589 | 0.81 | METAP1 (1.00) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL11598594 | 0.81 | METAP1 (1.00) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL17762754 | 0.80 | MAPT (0.63) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL8064186 | 0.79 | CMA1 (0.61) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL16160388 | 0.79 | PARP1 (0.75) | MAPTAPPSNCAMAPK1ALDH1A1 | |
| SCHEMBL16149331 | 0.79 | PARP1 (0.75) | MAPTAPPSNCAMAPK1ALDH1A1 | |
| SCHEMBL4044276 | 0.78 | METAP1 (1.00) | MAPTAPPSNCAMETAP1MAPK1 | |
| SCHEMBL13848519 | 0.78 | METAP1 (1.00) | MAPTAPPSNCAMETAP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014164667-A1 | DENGUE AND WEST NILE VIRUS PROTEASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2014-10-09 | — | — | WO | disclosed |