Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 6/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1775412 | 0.99 | GUSB (0.41) | GUSBPOLBKMT2AHRH4SCN1A | |
| SCHEMBL1776236 | 0.89 | GUSB (0.42) | GUSBHTR6 | |
| Hydrochloric Acid SCHEMBL1774071 | 0.89 | GUSB (0.42) | GUSBHTR6 | |
| SCHEMBL1775535 | 0.82 | FLT3 (0.46) | GUSBPOLBKMT2AHRH4DRD2 | |
| Hydrochloric Acid SCHEMBL1773881 | 0.81 | FLT3 (0.45) | GUSBPOLBKMT2AHRH4DRD2 | |
| SCHEMBL1776012 | 0.76 | GUSB (0.43) | GUSBHRH4DRD2HTR2AHTR7 | |
| SCHEMBL5015937 | 0.76 | HRH4 (0.46) | POLBHRH4DRD2HTR2ADRD3 | |
| SCHEMBL1775401 | 0.76 | HRH4 (0.45) | POLBKMT2AHRH4DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL1775921 | 0.76 | GUSB (0.42) | GUSBHRH4DRD2HTR2AHTR7 | |
| SCHEMBL1777263 | 0.75 | HTR2C (0.42) | GUSBDRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |