Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 15/20 | 0.80 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.76 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776095 | 0.95 | GABRA1 (0.79) | GABRA1GABRA5 | |
| SCHEMBL1776648 | 0.91 | ITGA5 (0.83) | GABRA1GABRA5ITGA5 | |
| SCHEMBL1776675 | 0.90 | ITGA5 (0.81) | GABRA1GABRA5ITGA5 | |
| SCHEMBL1777844 | 0.90 | GABRA5 (0.77) | GABRA1GABRA5ITGA5 | |
| Alogabat SCHEMBL20241000 | 0.89 | GABRA1 (1.00) | GABRA1ITGA5 | |
| Alogabat SCHEMBL29500971 | 0.89 | GABRA1 (1.00) | GABRA1ITGA5 | |
| SCHEMBL20241011 | 0.87 | GABRA1 (1.00) | GABRA1ITGA5 | |
| SCHEMBL29421367 | 0.87 | GABRA1 (1.00) | GABRA1ITGA5 | |
| SCHEMBL20241266 | 0.87 | GABRA1 (1.00) | GABRA1ITGA5 | |
| SCHEMBL29421351 | 0.87 | GABRA1 (1.00) | GABRA1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |