Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL17766639 | 1.00 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Bromide SCHEMBL29526881 | 1.00 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Bromide SCHEMBL29526851 | 1.00 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29527198 | 0.99 | DPP4 (0.42) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16098079 | 0.99 | DPP4 (0.42) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL29526691 | 0.99 | DPP4 (0.42) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL16098365 | 0.99 | DPP4 (0.42) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Iodide SCHEMBL29527142 | 0.97 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Iodide SCHEMBL29526714 | 0.97 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Iodide SCHEMBL17766600 | 0.97 | DPP4 (0.41) | DPP4ALDH1A1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10266498-B2 | Family of discriminating molecules for neutron and gamma rays and ionic liquids | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2019-04-23 | — | — | US | disclosed |
| US-20160145214-A1 | New Family of Discriminating Molecules for Neutron and Gamma Rays and Ionic Liquids | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2016-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145214-A1 | New Family of Discriminating Molecules for Neutron and Gamma Rays and Ionic Liquids | XRCC5, XRCC6, KPNA3 | SLC6A3 4066/4885DPP4 4608/4885ALDH1A1 4780/4885 |
| US-10266498-B2 | Family of discriminating molecules for neutron and gamma rays and ionic liquids | KPNA3, KPNA4, XRCC5 | SLC6A3 3779/4885DPP4 4650/4885ALDH1A1 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.