KPNA3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Molibresib (SCHEMBL1872390)	1.00	1/20
Molibresib (SCHEMBL12671490)	1.00	1/20
Molibresib (SCHEMBL12966358)	1.00	1/20
SCHEMBL9998851	0.91	1/20
SCHEMBL14756282	0.88	1/20
SCHEMBL15980874	0.88	1/20
SCHEMBL12966165	0.87	1/20
SCHEMBL14756215	0.87	1/20
SCHEMBL14756339	0.87	1/20
SCHEMBL15980861	0.87	1/20
SCHEMBL9998825	0.86	1/20
SCHEMBL15980893	0.86	1/20
SCHEMBL15980803	0.86	1/20
SCHEMBL1874116	0.85	1/20
SCHEMBL12671221	0.85	1/20
SCHEMBL14756021	0.85	1/20
SCHEMBL14756240	0.85	1/20
SCHEMBL14756287	0.85	1/20
SCHEMBL14756335	0.85	1/20
SCHEMBL14756409	0.85	1/20

Clinical trials — most relevant to KPNA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection	PHASE3	COMPLETED
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	PHASE2	COMPLETED
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma	PHASE1/PHASE2	RECRUITING
Efficacy of Ivermectin in COVID-19	PHASE1/PHASE2	COMPLETED
Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome	PHASE2	COMPLETED
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）	nan	RECRUITING
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion	nan	RECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk	nan	NOT_YET_RECRUITING
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
A Study on the Prevalence of Mutation of Cerebrotendinous Xanthomatosis (CTX)	nan	UNKNOWN
Chordoma Family Study	nan	COMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Induced Pluripotent Stem Cells for Niemann Pick Disease	nan	COMPLETED
Biomarker for Niemann Pick Type C Disease (BioNPC)	nan	WITHDRAWN
Genetics of Ehlers-Danlos Syndrome	nan	COMPLETED
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum	nan	COMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East	nan	UNKNOWN
Nerve Ultrasound in Acquired and Genetic Sensory Neuronopathies	nan	NOT_YET_RECRUITING
Mackenzie's Mission: The Australian Reproductive Carrier Screening Project	nan	COMPLETED
Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders	nan	RECRUITING
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING
Whole Genome Sequencing in the Neonatal Intensive Care Unit	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KPNA3 binder may also engage these)

Protein	Name	Similarity
O35344	—	1.000	O35344 →
P52295	—	1.000	P52295 →
KPNA4	Importin subunit alpha-3	1.000	landscape →
O14063	—	1.000	O14063 →
A9QM74	—	1.000	A9QM74 →
O35343	—	1.000	O35343 →
O94374	—	0.999	O94374 →
Q9FWY7	—	0.998	Q9FWY7 →
Q02821	—	0.998	Q02821 →
Q76P29	—	0.997	Q76P29 →
P52171	—	0.997	P52171 →
C6K7I2	—	0.997	C6K7I2 →
B6HJ92	—	0.996	B6HJ92 →
O80480	—	0.996	O80480 →
Q19969	—	0.995	Q19969 →
P52170	—	0.994	P52170 →
O04294	—	0.993	O04294 →
G5EB89	—	0.992	G5EB89 →
Q9FJ09	—	0.992	Q9FJ09 →
P91276	—	0.992	P91276 →
C0LLJ0	—	0.989	C0LLJ0 →
C1JZ66	—	0.989	C1JZ66 →
Q557F4	—	0.988	Q557F4 →
KPNA2	Importin subunit alpha-1	0.988	landscape →
Q9M9X7	—	0.988	Q9M9X7 →
O14089	—	0.986	O14089 →
P52293	—	0.983	P52293 →
F4JL11	—	0.982	F4JL11 →
Q8H0U4	—	0.981	Q8H0U4 →
Q06142	—	0.980	Q06142 →