KPNA4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21943538	0.59	1/20
SCHEMBL21943762	0.57	1/20
SCHEMBL21944043	0.55	1/20
SCHEMBL21943004	0.55	1/20
SCHEMBL21942995	0.53	1/20
SCHEMBL21943411	0.53	1/20
SCHEMBL14042267	0.52	1/20
SCHEMBL21943429	0.52	1/20
SCHEMBL22066328	0.51	1/20
SCHEMBL21943540	0.49	1/20
SCHEMBL21943537	0.45	1/20
SCHEMBL1454562	0.42	1/20
SCHEMBL17612956	0.42	1/20
SCHEMBL12399198	0.42	1/20
SCHEMBL29911712	0.40	1/20

Clinical trials — most relevant to KPNA4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection	PHASE3	COMPLETED
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	PHASE2	COMPLETED
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma	PHASE1/PHASE2	RECRUITING
Efficacy of Ivermectin in COVID-19	PHASE1/PHASE2	COMPLETED
Effects of an Intensified Treatment With ACE-I,ATA II and Statins in Alport Syndrome	PHASE2	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA）	nan	RECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk	nan	NOT_YET_RECRUITING
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion	nan	RECRUITING
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China	nan	COMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients	nan	RECRUITING
A Study on the Prevalence of Mutation of Cerebrotendinous Xanthomatosis (CTX)	nan	UNKNOWN
Induced Pluripotent Stem Cells for Niemann Pick Disease	nan	COMPLETED
Hydroxychloroquin (HCQ) in chILD of Genetic Defect	nan	COMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)	nan	WITHDRAWN
Genetics of Ehlers-Danlos Syndrome	nan	COMPLETED
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Biomarker for Niemann Pick Type C Disease (BioNPC)	nan	WITHDRAWN
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Chordoma Family Study	nan	COMPLETED
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Genetic Investigations in Children With Developmental and Epileptic Encephalopathies in Ho Chi Minh City, Vietnam	nan	UNKNOWN
Whole Genome Sequencing in the Neonatal Intensive Care Unit	nan	COMPLETED
Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East	nan	UNKNOWN
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)	nan	COMPLETED
Von Hippel-Lindau (VHL): Clinical Manifestations, Diagnosis, Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a KPNA4 binder may also engage these)

Protein	Name	Similarity
O35344	—	1.000	O35344 →
O35343	—	1.000	O35343 →
KPNA3	Importin subunit alpha-4	1.000	landscape →
O94374	—	1.000	O94374 →
P52171	—	0.998	P52171 →
P52295	—	0.997	P52295 →
O14063	—	0.997	O14063 →
A9QM74	—	0.995	A9QM74 →
O80480	—	0.994	O80480 →
Q02821	—	0.993	Q02821 →
Q76P29	—	0.993	Q76P29 →
C6K7I2	—	0.992	C6K7I2 →
B6HJ92	—	0.992	B6HJ92 →
P52170	—	0.991	P52170 →
O04294	—	0.991	O04294 →
Q19969	—	0.990	Q19969 →
Q9FWY7	—	0.989	Q9FWY7 →
C1JZ66	—	0.989	C1JZ66 →
Q9M9X7	—	0.989	Q9M9X7 →
Q9FJ09	—	0.988	Q9FJ09 →
P91276	—	0.985	P91276 →
C0LLJ0	—	0.985	C0LLJ0 →
P52293	—	0.985	P52293 →
G5EB89	—	0.983	G5EB89 →
F4JL11	—	0.981	F4JL11 →
Q8H0U4	—	0.980	Q8H0U4 →
KPNA2	Importin subunit alpha-1	0.979	landscape →
O14089	—	0.979	O14089 →
Q9SLX0	—	0.978	Q9SLX0 →
Q71VM4	—	0.977	Q71VM4 →