Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754282 | 1.00 | KARS1 (0.40) | KARS1MAP3K12ABL1MTORMAPK1 | |
| SCHEMBL17767957 | 0.91 | ABL1 (0.37) | ABL1MTORMAPK1WNT3AGSK3B | |
| SCHEMBL17768178 | 0.91 | ABL1 (0.37) | ABL1MTORMAPK1WNT3AGSK3B | |
| SCHEMBL17768095 | 0.91 | ABL1 (0.37) | ABL1MTORMAPK1WNT3AGSK3B | |
| SCHEMBL17778911 | 0.91 | ABL1 (0.36) | MAP3K12ABL1MTORMAPK1WNT3A | |
| SCHEMBL19689785 | 0.91 | ABL1 (0.36) | MAP3K12ABL1MTORMAPK1WNT3A | |
| SCHEMBL17618509 | 0.90 | WNT3A (0.41) | KARS1ABL1WNT3AMEN1KMT2A | |
| SCHEMBL19689811 | 0.90 | DYRK1A (0.42) | ABL1MTORMAPK1WNT3AGSK3B | |
| SCHEMBL17778803 | 0.90 | DYRK1A (0.42) | ABL1MTORMAPK1WNT3AGSK3B | |
| SCHEMBL17778888 | 0.90 | PIM1 (0.38) | MAP3K12ABL1MTORMAPK1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |