Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | KIF18A | Q8NI77 | 3/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778774 | 1.00 | NPY2R (0.36) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL17778837 | 0.93 | ALDH1A1 (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL19689804 | 0.91 | ALDH1A1 (0.37) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL19689769 | 0.91 | NPY2R (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL17768001 | 0.90 | ALDH1A1 (0.36) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL17768197 | 0.89 | KIF18A (0.39) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL19689672 | 0.88 | ALDH1A1 (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL19689671 | 0.88 | ALDH1A1 (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL17778530 | 0.88 | ALDH1A1 (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD | |
| SCHEMBL19706612 | 0.88 | ALDH1A1 (0.35) | NPY2RALDH1A1KDM4ECYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221316-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |