Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 6/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TACR3 | P29371 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706612 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL19689672 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL19689671 | 1.00 | ALDH1A1 (0.35) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL19689761 | 0.99 | ALDH1A1 (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL19689759 | 0.99 | ALDH1A1 (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL17778623 | 0.96 | KIF11 (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL20720962 | 0.96 | KIF11 (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL17769303 | 0.96 | KIF11 (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL17768072 | 0.93 | KDR (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 | |
| SCHEMBL19689807 | 0.93 | KDR (0.34) | ALDH1A1KDM4ECYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ALDH1A1 993/4885KDM4E 1355/4885CYP2C9 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.