Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 9/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776679 | 0.91 | GABRA5 (0.63) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1776363 | 0.89 | GABRA1 (0.60) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1776592 | 0.88 | ITGA5 (0.61) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1776663 | 0.86 | GABRA5 (0.63) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1779475 | 0.84 | GABRA1 (0.61) | GABRA5GABRA1 | |
| SCHEMBL1776773 | 0.81 | GABRA5 (0.76) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1778273 | 0.79 | GABRA5 (0.61) | GABRA5GABRA1 | |
| SCHEMBL1776628 | 0.79 | GABRA1 (0.58) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1777284 | 0.79 | GABRA5 (0.75) | GABRA5GABRA1ITGA5 | |
| SCHEMBL1776329 | 0.78 | ITGA5 (0.65) | GABRA5GABRA1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |