Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.50 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776894 | 0.85 | GABRA5 (0.53) | ITGA5GABRA5ENPP2 | |
| SCHEMBL1776792 | 0.82 | GABRA5 (0.51) | ITGA5GABRA5ENPP2 | |
| SCHEMBL1777271 | 0.79 | GABRA5 (0.47) | ITGA5GABRA5 | |
| SCHEMBL2928387 | 0.75 | GABRA5 (0.81) | ITGA5GABRA5 | |
| SCHEMBL1778385 | 0.74 | GABRA1 (0.70) | GABRA1ITGA5GABRA5 | |
| SCHEMBL6415912 | 0.72 | CNR2 (0.62) | CNR1CNR2 | |
| SCHEMBL7859783 | 0.71 | GABRA5 (0.53) | GABRA1GABRA5 | |
| SCHEMBL1776252 | 0.70 | GABRA1 (0.70) | GABRA1ITGA5GABRA5 | |
| SCHEMBL1776320 | 0.70 | GABRA5 (0.58) | ITGA5GABRA5 | |
| SCHEMBL1777284 | 0.70 | GABRA5 (0.75) | GABRA1ITGA5GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | claimed |
| US-7943619-B2 | Isoxazolo-pyridazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-17 | — | — | US | disclosed |