Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | GAK | O14976 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1034663 | 0.90 | SLC40A1 (0.45) | SLC40A1PIM1PIM2 | |
| SCHEMBL17772310 | 0.85 | FABP1 (0.39) | KDM4EALDH1A1HPGDHSD17B10PKM | |
| Tert-Butyl Formate SCHEMBL27830718 | 0.83 | SLC40A1 (0.40) | SLC40A1PIM1 | |
| SCHEMBL1031607 | 0.80 | SLC40A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10MAP4K4 | |
| SCHEMBL1035231 | 0.77 | SLC40A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10SLC40A1 | |
| SCHEMBL27830716 | 0.73 | SLC40A1 (0.40) | SLC40A1PIM1 | |
| SCHEMBL1035477 | 0.73 | SLC40A1 (0.40) | KDM4EHPGDSLC40A1PIM1 | |
| SCHEMBL17772298 | 0.65 | SMN1; SMN2 (0.51) | ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1034313 | 0.63 | SLC40A1 (0.49) | SLC40A1 | |
| SCHEMBL1074809 | 0.62 | SLC40A1 (0.48) | SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2273992-B1 | QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-25 | — | — | EP | disclosed |