Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MYLK | Q15746 | 1/20 | 0.35 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17772304 | 0.85 | KDM4E (0.37) | KDM4EALDH1A1HPGDHSD17B10PKM | |
| SCHEMBL1034663 | 0.82 | SLC40A1 (0.45) | PIM2CHRM3 | |
| Tert-Butyl Formate SCHEMBL27830718 | 0.76 | SLC40A1 (0.40) | MMP2CHRM3 | |
| SCHEMBL1031607 | 0.73 | SLC40A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10MAP4K4 | |
| SCHEMBL1035231 | 0.70 | SLC40A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10PIM2 | |
| SCHEMBL17174075 | 0.68 | MAP4K4 (0.56) | HSD17B10PIK3CAMAP4K4PIK3CG | |
| SCHEMBL1035477 | 0.68 | SLC40A1 (0.40) | KDM4EHPGDMMP2 | |
| SCHEMBL4434026 | 0.67 | PDE4D (0.56) | KDM4EALDH1A1HPGDHSD17B10PIK3CA | |
| SCHEMBL17174076 | 0.66 | MAP4K4 (0.54) | PIK3CAMAP4K4MKNK2MTORPIK3CG | |
| SCHEMBL17772337 | 0.64 | KDR (0.53) | KDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2273992-B1 | QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-25 | — | — | EP | disclosed |