SCHEMBL17772471

SCHEMBL17772471

Cc1c(F)c(F)c(C#N)c(C#N)c1F

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
TRPV4 Q9HBA0 1/20 0.32
ATM Q13315 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL406500 0.92 TRPV4 (0.31) ALDH1A1TRPV4
SCHEMBL24070354 0.92 ALDH1A1 (0.37) ALDH1A1TRPV4ATMKDM4E
SCHEMBL1808331 0.92 TRPV4 (0.33) ALDH1A1TRPV4ATMKDM4E
SCHEMBL25613867 0.89 TRPV4 (0.32) ALDH1A1TRPV4ATMKDM4E
SCHEMBL12418989 0.88 ALDH1A1 (0.38) ALDH1A1TRPV4ATMKDM4E
SCHEMBL25613914 0.86 ALDH1A1 (0.34) ALDH1A1TRPV4ATM
SCHEMBL16627106 0.86 TRPV4 (0.31) ALDH1A1TRPV4
SCHEMBL26415129 0.86 ALDH1A1 (0.34) ALDH1A1TRPV4ATM
SCHEMBL14168408 0.86 TRPV4 (0.33) ALDH1A1TRPV4ATMKDM4E
SCHEMBL26415130 0.86 TRPV4 (0.33) ALDH1A1TRPV4ATMKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3886194-A2 FLUORINATED AROMATIC SMALL MOLECULES AS FUNCTIONAL ADDITIVES FOR DISPERSION OF CONDUCTIVE POLYMERS Heraeus Deutschland GmbH & Co KG (DE) 2021-09-29 EP disclosed
US-10658598-B2 Fluorinated aromatic small molecules as functional additives for dispersion of conductive polymers HERAEUS DEUTSCHLAND GMBH & CO. KG. (DE) 2020-05-19 US disclosed
US-10411196-B2 2019-09-10 US disclosed
US-20170365798-A1 FLUORINATED AROMATIC SMALL MOLECULES AS FUNCTIONAL ADDITIVES FOR DISPERSION OF CONDUCTIVE POLYMERS Heraeus Deutschland GmbH & Co. KG (DE) 2017-12-21 US disclosed
US-20170365798-A1 FLUORINATED AROMATIC SMALL MOLECULES AS FUNCTIONAL ADDITIVES FOR DISPERSION OF CONDUCTIVE POLYMERS Heraeus Deutschland GmbH & Co. KG (DE) 2017-12-21 US disclosed
EP-3024049-A1 Fluorinated aromatic small molecules as functional additives for dispersion of conductive polymers Heraeus Deutschland GmbH & Co. KG (DE) 2016-05-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10658598-B2 Fluorinated aromatic small molecules as functional additives for dispersion of conductive polymers SLCO4C1, SLCO2B1, SLCO2A1 ALDH1A1 2490/4885TRPV4 268/4885ATM 3067/4885
US-20170365798-A1 FLUORINATED AROMATIC SMALL MOLECULES AS FUNCTIONAL ADDITIVES FOR DISPERSION OF CONDUCTIVE POLYMERS SLCO4C1, SLCO2B1, SLCO2A1 ALDH1A1 2490/4885TRPV4 268/4885ATM 3067/4885
US-10411196-B2 SLCO4C1, SLCO2B1, SLCO2A1 ALDH1A1 2318/4885TRPV4 334/4885ATM 4083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.