SCHEMBL1808331

SCHEMBL1808331

Cc1c(F)c(F)c(C#N)c(F)c1F

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.33
ALDH1A1 P00352 1/20 0.32
ATM Q13315 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL406500 0.95 TRPV4 (0.31) TRPV4ALDH1A1
SCHEMBL17772471 0.92 ALDH1A1 (0.35) TRPV4ALDH1A1ATMKDM4E
SCHEMBL25613867 0.92 TRPV4 (0.32) TRPV4ALDH1A1ATMKDM4E
SCHEMBL16627106 0.89 TRPV4 (0.31) TRPV4ALDH1A1
SCHEMBL7068601 0.89 TRPV4 (0.31) TRPV4ALDH1A1
SCHEMBL14168408 0.88 TRPV4 (0.33) TRPV4ALDH1A1ATMKDM4EMEN1
SCHEMBL26415130 0.88 TRPV4 (0.33) TRPV4ALDH1A1ATMKDM4EMEN1
SCHEMBL11048587 0.86 TRPV4 (0.32) TRPV4ALDH1A1ATMKDM4E
SCHEMBL13989354 0.86 TRPV4 (0.32) TRPV4ALDH1A1ATMKDM4E
SCHEMBL18159203 0.85 TRPV4 (0.35) TRPV4ALDH1A1ATMKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6894195-B2 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol SYNGENTA LIMITED (GB) 2005-05-17 US claimed
EP-1332125-B1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LTD (GB) 2004-09-29 EP claimed
US-20040063993-A1 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol SYNGENTA LIMITED (GB) 2004-04-01 US claimed
EP-1332125-A1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL Syngenta Limited (GB) 2003-08-06 EP claimed
WO-2002034707-A1 PREPARATION OF 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL SYNGENTA LIMITED (GB) 2002-05-02 WO claimed
CN-112786795-B Organic electroluminescent device and aromatic compound for organic electroluminescent device 三星显示有限公司 2025-06-24 CN disclosed
US-11985893-B2 Organic electroluminescence device and aromatic compound for organic electroluminescence device SAMSUNG DISPLAY CO., LTD. (KR) 2024-05-14 US disclosed
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-09-28 US disclosed
US-20230242562-A1 Compound of Formula (I), a Semiconductor Material Comprising at Least One Compound of Formula (I), a Semiconductor Layer Comprising at Least One Compound of Formula (I) and an Electronic Device Comprising at Least One Compound of Formula (I) NOVALED GMBH (DE) 2023-08-03 US disclosed
US-20230225201-A1 Organic Light Emitting Diode and Device Comprising the Same NOVALED GMBH (DE) 2023-07-13 US disclosed
US-20230225201-A1 Organic Light Emitting Diode and Device Comprising the Same NOVALED GMBH (DE) 2023-07-13 US disclosed
US-20230137110-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-05-04 US disclosed
US-4783547-A Polyfluoroaromatic nitriles ICI AMERICAS INC. (US) 1988-11-08 US disclosed
US-4486355-A INSECTICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-12-04 US disclosed
EP-0119701-A1 Grignard syntheses IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-09-26 EP disclosed
EP-0032121-B1 SUBSTITUTED TETRAFLUOROBENZYL ALCOHOLS AND HALIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-05-16 EP disclosed
US-4385070-A CYCLOPROPANE DERIVATIVES AS INSECTICIDES IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-05-24 US disclosed
EP-0016513-B1 ESTERS OF HALOGENATED SUBSTITUTED CYCLOPROPANOIC ACIDS, THEIR PREPARATION AND USE AS INSECTICIDES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-06-23 EP disclosed
EP-0032121-A2 Substituted tetrafluorobenzyl alcohols and halides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-07-15 EP disclosed
EP-0016513-A2 Esters of halogenated substituted cyclopropanoic acids, their preparation and use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-10-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11985893-B2 Organic electroluminescence device and aromatic compound for organic electroluminescence device CTCF, LEF1, BRD4 TRPV4 956/4885ALDH1A1 504/4885ATM 3497/4885
US-20040063993-A1 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol METTL14, CYP4F2, METTL3 TRPV4 1398/4885ALDH1A1 2288/4885ATM 3370/4885
US-20230137110-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE THEREOF SLCO2B1, SLCO2A1, SLCO1B3 TRPV4 112/4885ALDH1A1 1189/4885ATM 3668/4885
US-20230242562-A1 Compound of Formula (I), a Semiconductor Material Comprising at Least One Compound of Formula (I), a Semiconductor Layer Comprising at Least One Compound of Formula (I) and an Electronic Device Comprising at Least One Compound of Formula (I) AFF4, AFF1, AFF2 TRPV4 573/4885ALDH1A1 722/4885ATM 2587/4885
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE OCIAD1, OCIAD2, SLCO4C1 TRPV4 128/4885ALDH1A1 457/4885ATM 3188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.