Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743086 | 0.94 | AURKA (0.45) | MAPTRECQLKDM4EKMT2AMAPK1 | |
| SCHEMBL1780074 | 0.90 | SMN1; SMN2 (0.43) | RXFP1MAPTRECQLKDM4ETSHR | |
| SCHEMBL1779700 | 0.88 | AURKA (0.50) | RXFP1MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL15362130 | 0.88 | RXFP1 (0.45) | RXFP1MAPTRECQLKDM4ETSHR | |
| SCHEMBL1779328 | 0.87 | RXFP1 (0.44) | RXFP1KDM4EALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL1780795 | 0.87 | AURKA (0.45) | RXFP1CYP2C19NPSR1AURKAPOLB | |
| SCHEMBL3869847 | 0.87 | MAPK1 (0.49) | RXFP1MAPTRECQLKDM4ETSHR | |
| SCHEMBL1778129 | 0.86 | AURKA (0.43) | RXFP1HSD17B10ALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL1781440 | 0.86 | AURKA (0.55) | AURKAABL1BCR | |
| SCHEMBL1779492 | 0.86 | AURKA (0.44) | RXFP1KDM4EAURKAABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |