Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777256 | 0.90 | RXFP1 (0.47) | SMN1; SMN2RXFP1MEN1KMT2AMAPK1 | |
| SCHEMBL15362166 | 0.89 | MEN1 (0.41) | SMN1; SMN2RXFP1MEN1KMT2ATDP1 | |
| SCHEMBL1778942 | 0.88 | RXFP1 (0.38) | SMN1; SMN2RXFP1MAPK1KDM4EHSD17B10 | |
| SCHEMBL1779339 | 0.87 | INSR (0.45) | — | |
| SCHEMBL1778010 | 0.85 | RAB9A (0.37) | SMN1; SMN2MEN1KMT2AMAPK1KDM4E | |
| SCHEMBL1779132 | 0.85 | NR1H4 (0.37) | RXFP1MAPK1NPSR1 | |
| SCHEMBL1778845 | 0.85 | PPARG (0.37) | SMN1; SMN2KMT2AMAPK1KDM4EPOLB | |
| SCHEMBL1778788 | 0.85 | FGFR4 (0.36) | SMN1; SMN2MEN1KMT2AMAPK1KDM4E | |
| SCHEMBL743086 | 0.83 | AURKA (0.45) | SMN1; SMN2MEN1KMT2ATDP1MAPK1 | |
| SCHEMBL3869847 | 0.83 | MAPK1 (0.49) | SMN1; SMN2RXFP1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |