Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777605 | 0.88 | NR4A2 (0.47) | KDM4EHSD17B10LMNAHTR4KMT2A | |
| SCHEMBL1777482 | 0.85 | LMNA (0.52) | KDM4EHSD17B10LMNAKMT2ACPT1A | |
| SCHEMBL1777004 | 0.84 | KDM4E (0.53) | KDM4EHSD17B10LMNAKMT2ACPT1A | |
| Potassium Ion SCHEMBL1779429 | 0.84 | NR4A2 (0.47) | KDM4EHSD17B10LMNAKMT2ACPT1A | |
| SCHEMBL13157658 | 0.83 | NR4A2 (0.46) | KDM4EHSD17B10LMNAKMT2ACPT1A | |
| SCHEMBL1777620 | 0.82 | IGF1R (0.58) | KDM4EHSD17B10LMNAAURKAMET | |
| SCHEMBL1778147 | 0.81 | NR4A2 (0.47) | KDM4EHSD17B10LMNAKMT2ACPT1A | |
| SCHEMBL1779530 | 0.78 | MAP3K14 (0.53) | KDM4EHSD17B10KMT2AKDRMEN1 | |
| SCHEMBL1779702 | 0.77 | MAP3K14 (0.52) | KDM4EHSD17B10LMNAKMT2AMEN1 | |
| SCHEMBL1778255 | 0.76 | KDR (0.47) | KDM4EHSD17B10LMNAKMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |