Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | AURKA | O14965 | 5/20 | 0.47 |
| ▸ | TEK | Q02763 | 5/20 | 0.47 |
| ▸ | MET | P08581 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778752 | 0.91 | ALDH1A1 (0.46) | KDRAURKATEKMETLCK | |
| SCHEMBL1779027 | 0.88 | L3MBTL1 (0.44) | KDRAURKATEKMETAURKB | |
| SCHEMBL1777905 | 0.86 | KDM4E (0.48) | AURKBLCKKDM4EHSD17B10LMNA | |
| SCHEMBL1779368 | 0.86 | L3MBTL1 (0.51) | AURKBLCKKDM4EHSD17B10LMNA | |
| SCHEMBL1780157 | 0.84 | SYK (0.45) | KDRAURKATEKMETAURKB | |
| SCHEMBL1777620 | 0.82 | IGF1R (0.58) | KDRAURKATEKMETAURKB | |
| SCHEMBL1779704 | 0.78 | GSK3A (0.43) | AURKAMETAURKBLCKKDM4E | |
| SCHEMBL1777397 | 0.76 | KDM4E (0.60) | KDRAURKATEKMETKDM4E | |
| SCHEMBL1779605 | 0.75 | PIM1 (0.42) | AURKAMETAURKBLCKKDM4E | |
| SCHEMBL1776936 | 0.75 | IGF1R (0.58) | AURKAMETAURKBLCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-6897207-B2 | Azaindoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |