Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17776413 | 1.00 | MEN1 (0.35) | MEN1KMT2ATSHRALDH1A1TP53 | |
| SCHEMBL23937575 | 0.87 | ALDH1A1 (0.41) | TSHRALDH1A1 | |
| SCHEMBL16665814 | 0.87 | ALDH1A1 (0.37) | TSHRALDH1A1 | |
| SCHEMBL23768523 | 0.87 | — | — | |
| SCHEMBL16665812 | 0.87 | ALDH1A1 (0.37) | TSHRALDH1A1 | |
| SCHEMBL16557254 | 0.83 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL20353236 | 0.82 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL22423220 | 0.82 | LMNA (0.40) | MEN1KMT2A | |
| SCHEMBL17776400 | 0.82 | TSHR (0.52) | TSHR | |
| SCHEMBL19658294 | 0.82 | TSHR (0.52) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205191-A1 | INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES | MERCK SHARP & DOHME CORP. (US) | 2017-11-30 | — | — | WO | disclosed |
| WO-2016081670-A2 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-05-26 | — | — | WO | disclosed |