Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 11/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 7/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770383 | 1.00 | OPRK1 (0.37) | OPRK1MALT1GSK3BCDK5DYRK1A | |
| SCHEMBL17775011 | 0.91 | SORT1 (0.34) | MALT1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17770219 | 0.91 | SORT1 (0.34) | MALT1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL19736466 | 0.88 | MALT1 (0.40) | MALT1 | |
| SCHEMBL22239748 | 0.88 | JAK2 (0.38) | MALT1JAK2TYK2 | |
| SCHEMBL17770220 | 0.85 | OPRK1 (0.39) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17776945 | 0.85 | OPRK1 (0.39) | OPRK1GSK3BCDK5DYRK1ACDK5R1 | |
| SCHEMBL17769352 | 0.84 | OPRK1 (0.42) | OPRK1 | |
| SCHEMBL17769757 | 0.84 | OPRK1 (0.42) | OPRK1 | |
| SCHEMBL17769960 | 0.84 | CBLB (0.31) | MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |