Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 14/20 | 0.42 |
| ▸ | HTR2A | P28223 | 12/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770256 | 1.00 | HTR2C (0.42) | HTR2CHTR2ACYP1A2MAPTALDH1A1 | |
| SCHEMBL22239519 | 0.90 | HTR2C (0.42) | HTR2CHTR2ACYP1A2MAPTALDH1A1 | |
| SCHEMBL17770242 | 0.90 | HTR2C (0.42) | HTR2CHTR2ACYP1A2MAPTALDH1A1 | |
| SCHEMBL17770236 | 0.85 | KDM4E (0.37) | KDM4E | |
| SCHEMBL22239612 | 0.85 | KDM4E (0.37) | KDM4E | |
| SCHEMBL17768200 | 0.85 | HTR2C (0.48) | HTR2CHTR2A | |
| SCHEMBL17770422 | 0.85 | OPRK1 (0.36) | KDM4ETSHR | |
| SCHEMBL16249988 | 0.85 | HTR2C (0.48) | HTR2CHTR2A | |
| SCHEMBL17778725 | 0.85 | HTR2C (0.48) | HTR2CHTR2A | |
| SCHEMBL17777041 | 0.82 | MEN1 (0.39) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |