Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770236 | 1.00 | KDM4E (0.37) | KDM4EHTTHSD17B10FAAHMEN1 | |
| SCHEMBL17776937 | 0.91 | RXFP1 (0.37) | KDM4EFAAHMEN1KMT2ARXFP1 | |
| SCHEMBL22239604 | 0.90 | FAAH (0.39) | KDM4EFAAHKMT2ARXFP1TP53 | |
| SCHEMBL17769875 | 0.90 | FAAH (0.39) | KDM4EFAAHKMT2ARXFP1TP53 | |
| SCHEMBL19736459 | 0.88 | CNR2 (0.36) | KDM4EFAAH | |
| SCHEMBL16754416 | 0.88 | PRKD1 (0.36) | KDM4EHTTHSD17B10FAAHMEN1 | |
| SCHEMBL17777041 | 0.88 | MEN1 (0.39) | KDM4EFAAHMEN1KMT2ATP53 | |
| SCHEMBL17770238 | 0.86 | SMYD3 (0.37) | FAAHKMT2A | |
| SCHEMBL17770220 | 0.85 | OPRK1 (0.39) | CDK5CDK5R1 | |
| SCHEMBL17776945 | 0.85 | OPRK1 (0.39) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |