Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754508 | 1.00 | KMT2A (0.38) | KMT2AFAAHKDM4EPIM3MEN1 | |
| SCHEMBL16237541 | 1.00 | KMT2A (0.38) | KMT2AFAAHKDM4EPIM3MEN1 | |
| SCHEMBL22239604 | 0.87 | FAAH (0.39) | KMT2AFAAHKDM4ERXFP1 | |
| SCHEMBL17769875 | 0.87 | FAAH (0.39) | KMT2AFAAHKDM4ERXFP1 | |
| SCHEMBL16238221 | 0.87 | GRM5 (0.42) | KMT2AFAAHMEN1RAB9A | |
| SCHEMBL17778336 | 0.87 | GRM5 (0.42) | KMT2AFAAHMEN1RAB9A | |
| SCHEMBL16238325 | 0.87 | GRM5 (0.42) | KMT2AFAAHMEN1RAB9A | |
| SCHEMBL17776937 | 0.86 | RXFP1 (0.37) | KMT2AFAAHKDM4EMEN1RAB9A | |
| SCHEMBL17618595 | 0.86 | KMT2A (0.36) | KMT2AFAAHKDM4EMEN1RAB9A | |
| SCHEMBL19699670 | 0.86 | FAAH (0.38) | FAAHPIM3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |