Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769875 | 1.00 | FAAH (0.39) | FAAHKARS1RXFP1CASRKDM4E | |
| SCHEMBL17776937 | 0.91 | RXFP1 (0.37) | FAAHRXFP1KDM4EKMT2ATP53 | |
| SCHEMBL17770236 | 0.90 | KDM4E (0.37) | FAAHRXFP1KDM4EKMT2ACDK5 | |
| SCHEMBL22239612 | 0.90 | KDM4E (0.37) | FAAHRXFP1KDM4EKMT2ACDK5 | |
| SCHEMBL17770238 | 0.89 | SMYD3 (0.37) | FAAHKMT2ACYP2D6 | |
| SCHEMBL16754636 | 0.88 | KARS1 (0.38) | FAAHKARS1GSK3B | |
| SCHEMBL19714191 | 0.87 | HSD11B1 (0.36) | FAAHKMT2ACYP3A4CYP2C9 | |
| SCHEMBL19736459 | 0.87 | CNR2 (0.36) | FAAHKDM4E | |
| SCHEMBL16754464 | 0.87 | TRPV1 (0.39) | FAAHKDM4EKMT2ATP53L3MBTL1 | |
| SCHEMBL17775617 | 0.87 | TRPV1 (0.39) | FAAHKDM4EKMT2ATP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |