Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769875 | 0.91 | FAAH (0.39) | RXFP1FAAHKDM4ETP53L3MBTL1 | |
| SCHEMBL22239604 | 0.91 | FAAH (0.39) | RXFP1FAAHKDM4ETP53L3MBTL1 | |
| SCHEMBL17770236 | 0.91 | KDM4E (0.37) | RXFP1FAAHKDM4ETP53MEN1 | |
| SCHEMBL22239612 | 0.91 | KDM4E (0.37) | RXFP1FAAHKDM4ETP53MEN1 | |
| SCHEMBL19736459 | 0.88 | CNR2 (0.36) | FAAHKDM4ENPC1RAB9A | |
| SCHEMBL17770238 | 0.88 | SMYD3 (0.37) | FAAHRAB9AHRH2HRH1KMT2A | |
| SCHEMBL16776516 | 0.88 | KARS1 (0.37) | FAAH | |
| SCHEMBL17776973 | 0.87 | TRPV1 (0.39) | FAAHKDM4ENPC1RAB9ATP53 | |
| SCHEMBL19714191 | 0.86 | HSD11B1 (0.36) | FAAHHRH2HRH1MEN1KMT2A | |
| SCHEMBL16754508 | 0.86 | KMT2A (0.38) | RXFP1FAAHKDM4ERAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |