Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | WNT3A | P56704 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754615 | 1.00 | L3MBTL1 (0.35) | L3MBTL1ABL1USP30WNT3AKDM4E | |
| SCHEMBL19706757 | 0.92 | IRAK4 (0.34) | ABL1USP30WNT3AIRAK4MAP4K4 | |
| SCHEMBL17768050 | 0.92 | IRAK4 (0.34) | ABL1USP30WNT3AIRAK4MAP4K4 | |
| SCHEMBL16754671 | 0.89 | HRH3 (0.38) | ABL1USP30WNT3AKDM4EALDH1A1 | |
| SCHEMBL17778671 | 0.89 | EGFR (0.43) | IRAK4 | |
| SCHEMBL16754395 | 0.88 | IRAK4 (0.34) | ABL1USP30WNT3AIRAK4PIM1 | |
| SCHEMBL19706758 | 0.87 | GSK3B (0.35) | USP30WNT3AIRAK4 | |
| SCHEMBL17778751 | 0.87 | GSK3B (0.35) | USP30WNT3AIRAK4 | |
| SCHEMBL16754667 | 0.87 | USP30 (0.36) | ABL1USP30WNT3AIRAK4JAK3 | |
| SCHEMBL17768108 | 0.87 | WNT3A (0.43) | ABL1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |