Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13117743 | 0.81 | HDAC4 (0.52) | HCRTR1 | |
| SCHEMBL21765886 | 0.78 | PTK2 (0.49) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL19699546 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL20097426 | 0.76 | ATM (0.53) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL27350716 | 0.76 | RAB9A (0.57) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL1723145 | 0.76 | NOTUM (0.56) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL24120003 | 0.74 | ATM (0.42) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL18425134 | 0.73 | ACVR1 (0.49) | SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1722219 | 0.73 | RAB9A (0.55) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL17778922 | 0.72 | ADORA3 (0.45) | HSD17B10SMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |