Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 7/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.49 |
| ▸ | GSK3A | P49840 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | CDK8 | P49336 | 3/20 | 0.49 |
| ▸ | MST1R | Q04912 | 2/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327562 | 0.84 | TAS2R14 (0.49) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL12506975 | 0.84 | CLK4 (0.51) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL4551457 | 0.83 | SMN1; SMN2 (0.65) | GAASMN1; SMN2NPC1POLBRAB9A | |
| SCHEMBL13170010 | 0.82 | KDM4E (0.56) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL2635287 | 0.80 | TAS2R14 (0.57) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL2400372 | 0.80 | CLK4 (0.45) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL5031654 | 0.79 | P2RX7 (0.53) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL30071274 | 0.79 | SMN1; SMN2 (0.51) | GAASMN1; SMN2GRM5NPC1POLB | |
| SCHEMBL29640129 | 0.79 | P2RX7 (0.53) | ACVR1CLK4GSK3AGSK3BCDK8 | |
| SCHEMBL9891927 | 0.78 | GSK3A (0.52) | ACVR1CLK4GSK3AGSK3BCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328853-A1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2018-06-06 | — | — | EP | disclosed |
| WO-2017016669-A1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-02-02 | — | — | WO | disclosed |