Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17778638 | 0.83 | NUDT1 (0.34) | KDM4ENPC1RAB9A | |
| SCHEMBL17778688 | 0.79 | KDM4E (0.44) | KDM4ENPC1RAB9A | |
| SCHEMBL19783174 | 0.79 | KDM4E (0.33) | KDM4ENPC1RAB9A | |
| Hydrochloric Acid SCHEMBL30189819 | 0.77 | KDM4E (0.33) | KDM4ENPC1RAB9A | |
| SCHEMBL23634032 | 0.74 | KDM4E (0.38) | KDM4ENPC1RAB9A | |
| SCHEMBL22239544 | 0.74 | CHRNB2 (0.35) | KDM4ENPC1RAB9A | |
| SCHEMBL17778782 | 0.73 | FEN1 (0.32) | — | |
| SCHEMBL22239775 | 0.72 | CYP4F2 (0.39) | KDM4ENPC1RAB9A | |
| SCHEMBL19003447 | 0.71 | RAB9A (0.46) | KDM4ENPC1RAB9A | |
| SCHEMBL18654540 | 0.71 | CDK2 (0.31) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-07-22 | — | — | EP | disclosed |
| WO-2018013774-A1 | BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | disclosed |
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |