Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17769299 | 0.89 | ALDH1A1 (0.41) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL17769346 | 0.87 | SMN1; SMN2 (0.33) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL20733207 | 0.85 | KDM4E (0.39) | KDM4E | |
| SCHEMBL20720993 | 0.81 | JAK2 (0.35) | KDM4E | |
| SCHEMBL17778615 | 0.81 | JAK2 (0.35) | KDM4E | |
| SCHEMBL22239528 | 0.80 | PRKAB2 (0.35) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL17770328 | 0.80 | PRKAB2 (0.35) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL17769314 | 0.76 | CHRNB2 (0.33) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL17769304 | 0.74 | — | — | |
| SCHEMBL17769428 | 0.73 | CHRNB2 (0.33) | PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |