Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689652 | 1.00 | MAPK1 (0.39) | MAPK1SYKRAB9AKDM4ENPC1 | |
| SCHEMBL17778888 | 0.89 | PIM1 (0.38) | MAPK1WNT3AABL1PIM1PIM2 | |
| SCHEMBL19699674 | 0.89 | MAPK1 (0.37) | MAPK1WNT3AABL1PIM1PIM2 | |
| SCHEMBL17768176 | 0.87 | IDH1 (0.34) | MAPK1KCNH2WNT3AABL1CAMK1D | |
| SCHEMBL17778323 | 0.86 | KARS1 (0.40) | MAPK1SYKRAB9AKDM4ENPC1 | |
| SCHEMBL16754282 | 0.86 | KARS1 (0.40) | MAPK1SYKRAB9AKDM4ENPC1 | |
| SCHEMBL19706795 | 0.85 | PSEN1 (0.41) | MAPK1SYKMTOR | |
| SCHEMBL19689792 | 0.85 | PSEN1 (0.41) | MAPK1SYKMTOR | |
| SCHEMBL19706688 | 0.85 | WNT3A (0.43) | MAPK1SYKKCNH2WNT3AABL1 | |
| SCHEMBL19689656 | 0.85 | WNT3A (0.43) | MAPK1SYKKCNH2WNT3AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |